The safest way to prevent the deterioration of Parkinson's disease may be brought about by the inconspicuous cinnamon. Researchers have found that this commonly used spice can reduce the effects of Parkinson's disease in mice. Researchers at the University of Rush's Federal Medical Center used cinnamon powder to feed mice with Parkinson's disease (PD) and found that the compounds in the spice reversed some of the changes in the brain caused by this condition.
Cinnamon has been used to treat urea cycle disorders because it is metabolized to form sodium benzoate, which helps the body to get rid of excess ammonia in the blood. In this study, the researchers found that once cinnamon was metabolized to sodium benzoate, it entered the brain and stopped the synthesis of both proteins (Parkin and DJ-1), reducing the loss of brain tissue by Parkinson's. This substance also normalizes neurotransmitter levels and improves mouse motor function, researchers explained in a press conference.
"Now we need to translate this finding into clinical trials for patients with PD. If these results can be demonstrated in patients with PD, this will be a major advance in the treatment of this devastating neurodegenerative disease."
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